Factorial analysis of mild changes in the far peripheral retina on normal fluorescein angiography
Objective: To investigate the characteristics of the far peripheral retina when fundus fluorescein angiograms (FFA) were normal with 1-year follow-up.
Methods: 530 consecutive normal FFA (1060 eyes) were reviewed. Individuals were grouped according to age and sex and then to compare the changes in the peripheral retina, which included capillary telangiectasia, dye leakage from microaneurysms (MAs) or telangiectasia, avascular areas, and retinal vascular anastomosis. 188 eyes of 1060 eyes were followed up for 1 year.
Results: There was a statistically significant difference between normal and abnormal peripheral retina among the age groups (x2=25.277, p=0.000).
The 31-45 age group showed the most changes in the far peripheral retina, followed by the 16-30 age group; the 61 and older age group showed the fewest changes.
There was a statistically significant difference between male and female in different age groups (x2=7.077, p=0.008). There was a statistically significant difference in changes in the far peripheral retina among the various groups (x2=25.150, p=0.014). 188 eyes followed-up for 1 year, 3 patients (4 eyes) developed anterior uveitis, and 1 patient (2 eyes) developed intermediate uveitis.
Conclusions: Abnormal changes in normal FFA in the far peripheral retina are often observed.
Vasodilatation and MAs scarcely influenced visual function. If dye leakage and an non-perfusion (NP) area are found in the peripheral retina on a normal FFA, anterior uveitis or intermediate uveitis may develop.
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